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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSP90B1
All Species:
39.7
Human Site:
S552
Identified Species:
62.38
UniProt:
P14625
Number Species:
14
Phosphosite Substitution
Charge Score:
0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P14625
NP_003290.1
803
92469
S552
S
R
K
E
A
E
S
S
P
F
V
E
R
L
L
Chimpanzee
Pan troglodytes
XP_509323
803
92478
S552
S
R
K
E
A
E
S
S
P
F
V
E
R
L
L
Rhesus Macaque
Macaca mulatta
XP_001095189
804
92594
S552
S
R
K
E
A
E
S
S
P
F
V
E
R
L
L
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P08113
802
92457
S552
S
R
K
E
A
E
S
S
P
F
V
E
R
L
L
Rat
Rattus norvegicus
Q66HD0
804
92752
S552
S
R
K
E
A
E
S
S
P
F
V
E
R
L
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507634
816
93562
S568
S
R
K
E
A
E
S
S
P
F
V
E
R
L
L
Chicken
Gallus gallus
P08110
795
91537
S551
S
R
K
E
A
E
S
S
P
F
V
E
R
L
L
Frog
Xenopus laevis
NP_001083114
805
92996
S551
S
R
Q
E
V
E
S
S
P
F
V
E
R
L
L
Zebra Danio
Brachydanio rerio
Q90474
725
83300
I515
G
L
E
V
I
Y
M
I
E
P
I
D
E
Y
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P02828
717
81847
E508
F
E
V
V
Y
M
T
E
P
I
D
E
Y
V
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q18688
702
80265
D493
F
E
V
L
Y
M
C
D
P
I
D
E
Y
C
V
Sea Urchin
Strong. purpuratus
NP_999808
806
92314
S552
S
R
K
E
V
E
S
S
P
F
V
E
R
L
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q08277
715
81872
F506
K
K
G
Y
E
V
L
F
M
V
D
A
I
D
E
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9STX5
823
94185
S582
S
K
E
Q
L
E
K
S
P
F
L
E
R
L
I
Baker's Yeast
Sacchar. cerevisiae
P15108
705
80881
F496
A
K
N
F
E
V
L
F
L
T
D
P
I
D
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99.6
N.A.
N.A.
96.6
95.1
N.A.
90.5
90.5
85
44.2
N.A.
44.2
N.A.
43.2
65.2
Protein Similarity:
100
99.8
99.7
N.A.
N.A.
98.5
97.8
N.A.
95.4
95.1
94.1
62.5
N.A.
61.3
N.A.
61.5
81.3
P-Site Identity:
100
100
100
N.A.
N.A.
100
100
N.A.
100
100
86.6
0
N.A.
13.3
N.A.
13.3
93.3
P-Site Similarity:
100
100
100
N.A.
N.A.
100
100
N.A.
100
100
93.3
20
N.A.
33.3
N.A.
20
93.3
Percent
Protein Identity:
N.A.
46.8
N.A.
47.7
44.4
N.A.
Protein Similarity:
N.A.
63.1
N.A.
67.8
61.2
N.A.
P-Site Identity:
N.A.
0
N.A.
53.3
0
N.A.
P-Site Similarity:
N.A.
6.6
N.A.
86.6
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
0
47
0
0
0
0
0
0
7
0
0
0
% A
% Cys:
0
0
0
0
0
0
7
0
0
0
0
0
0
7
7
% C
% Asp:
0
0
0
0
0
0
0
7
0
0
27
7
0
14
0
% D
% Glu:
0
14
14
60
14
67
0
7
7
0
0
80
7
0
14
% E
% Phe:
14
0
0
7
0
0
0
14
0
67
0
0
0
0
0
% F
% Gly:
7
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
7
0
0
7
0
14
7
0
14
0
14
% I
% Lys:
7
20
54
0
0
0
7
0
0
0
0
0
0
0
0
% K
% Leu:
0
7
0
7
7
0
14
0
7
0
7
0
0
67
60
% L
% Met:
0
0
0
0
0
14
7
0
7
0
0
0
0
0
0
% M
% Asn:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
80
7
0
7
0
0
0
% P
% Gln:
0
0
7
7
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
60
0
0
0
0
0
0
0
0
0
0
67
0
0
% R
% Ser:
67
0
0
0
0
0
60
67
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
7
0
0
7
0
0
0
0
0
% T
% Val:
0
0
14
14
14
14
0
0
0
7
60
0
0
7
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
7
14
7
0
0
0
0
0
0
14
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _